University of Alabama, Tuscaloosa
This study aims to test whether aerobic exercise performed after fear extinction learning improves cognitive, physiological, and neural indices of extinction recall in a sample of trauma-exposed men and women with and without posttraumatic stress disorder (PTSD). Participants will complete a clinical intake visit (Day 0), followed by a three-day fear conditioning (day 1), fear extinction + activity (day 2), and fear extinction recall (day 3) protocol.
Inclusion Criteria for PTSD: * male or female sex * right-handed * age 18-64 * a current diagnosis of PTSD where the index event involves interpersonal violence exposure (e.g., physical/sexual assault). Inclusion criteria for the trauma-exposed (without PTSD) control participants includes: * male or female sex * right-handed * age 18-64 * interpersonal violence exposure (e.g., physical/sexual assault). Exclusion Criteria for all participants: * current substance use disorder (other than alcohol, nicotine, or cannabis) * acute suicidality * history of bipolar/psychotic disorder * changes t…
Participants will complete either a 30-minute bout of light-, moderate-, or high-intensity aerobic exercise at one of the visits.
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