Hyperbaric Oxygen Therapy in Acute Ischemic Stroke Recovery
LCMC Health
Summary
This study will critically examine the feasibility, safety and efficacy of HBOT during inpatient rehabilitation (IPR) after acute ischemic stroke measured by non-disruption of 3 hours of daily therapy, frequency of neurological deterioration or complications (seizure, hemorrhage, brain edema), and functional communication, activities of daily living (ADLs) and mobility.
Description
Preclinical studies support that HBOT augments several adaptive mechanisms following ischemic stroke, including neuroplasticity, cerebral angiogenesis, and regeneration of nerve fibers. The earlier the treatment, the greater potential for a therapeutic effect. However, logistical issues and safety concerns have prevented application of HBOT in the hyperacute window, particularly when coupled with recanalization therapy as the risk of hemorrhagic conversion is highest, monitoring intervals are short, and the natural history is being altered by another treatment. By enrolling patients who are in…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Age 18 years and above * Ischemic stroke proven on neuroimaging * Within 7-30 days post-stroke on day 1 of treatment * Admitted to Touro Inpatient Rehab Facility Exclusion Criteria: * Pre-stroke modified Rankin Scale Score \>2 * Parenchymal hemorrhagic transformation (PH1 or PH2) * Receptive aphasia such that recommendations for preventative measures to mitigate barotrauma cannot be followed * History of recurrent and unprovoked seizures requiring a change in management in the last 3 months to control seizures * Pulmonary disease requiring supplemental oxygen or daily…
Interventions
- DeviceHyperbaric Oxygen Therapy
Hyperbaric Oxygen Therapy
Location
- Touro Infirmary New OrleansNew Orleans, Louisiana