Changes in Microbial Status From Dentate, Edentulous and After Dental Implant Placement
Case Western Reserve University
Summary
The objectives of this study are to analyze the oral microbiome modulations occurring during the transition from partial (with some residual teeth) to full edentulous (without remaining teeth) status and implant placement in subjects affected by severe periodontitis; to evaluate if microbiome changes in relation to the used of different implant material/surface; and to assess the variance of the changes to determine the sample size for future longitudinal prospective studies.
Description
The introduction of dental implants has significantly changed the treatment approach for prosthetic rehabilitation of partially and edentulous patients. In the last decades an increasing number of patients have received implants for the replacement of missing teeth. Although dental implants have proved to be a very predictable treatment option, in the long term they are susceptible to biologic complications that may lead to implant loss. In particular, two major peri-implants conditions have been described: peri-implant mucositis and peri-implantitis. Peri-implant mucositis is an inflammatory…
Eligibility
- Age range
- 21+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: 1. At least 21 years of age 2. Diagnosis of Stage III or IV periodontitis based on full mouth probing and full mouth x-rays 3. Planned for full mouth extraction and replacement by dental implants. 4. Rehabilitation with Implant supported restorations either maxilla and/ or mandible. 5. At least 2 implants available for examination. 6. No bone augmentation required. Exclusion Criteria: 1. Conditions requiring chronic routine prophylactic use of antibiotics. 2. Conditions requiring prolonged use of steroids. 3. History of leukocyte dysfunction and deficiencies 4. Bleeding…
Interventions
- OtherMicrobial Sampling
Pool microbial sampling will be performed and changes in the microbiome will be evaluated and compared for differences
Location
- Case Western Reserve University Department of PeriodonticsCleveland, Ohio