Changes in Postprandial Hormone Levels in Cystic Fibrosis Related Diabetes.
University of Cincinnati
Summary
In this exploratory study, the hormonal responses to a mixed meal will be examined in people with cystic fibrosis. The aim of this study is to find correlates with impaired glucose tolerance that is associated with this population.
Description
The pancreas plays a key role in the regulation of whole-body glucose metabolism in humans. It contains 1 to 3 million islets, each of which contains several types of endocrine cells including insulin-secreting beta cells, glucagon-secreting alpha cells, and somatostatin- secreting delta cells. Insulin is released in response to a rise in blood glucose after a meal, and promotes glucose utilization by peripheral tissues (e.g., skeletal muscle), which allows the return of blood glucose to a fasting level. Glucagon is released when blood glucose falls below a normal fasting level (\~80-100 mg/dL…
Eligibility
- Age range
- 18–45 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Diagnosed with cystic fibrosis * Aged 18 to 45 years * Males and females of any race and ethnicity * Receiving highly effective CFTR modular therapy Exclusion Criteria: * Transplant recipient * Acute lung function decline or exacerbation within the last 3 months * Use of systemic glucocorticoids * Pregnancy * Known liver disease that would be expected to significantly impact metabolic variable as interpreted by a study doctor * The presence of any other disease or condition, as interpreted by any one of the study doctors, that would be expected to confound the response…
Interventions
- OtherMixed meal
Each individual will ingest 5 mL/kg of Boost energy drink.
Location
- University of CincinnatiCincinnati, Ohio