Contrast Ultrasound vs. Abbreviated MRI for Detection of HCC in Patients With Indeterminate Liver Nodules
University of Texas Southwestern Medical Center
Summary
The study will be conducted at the following locations: 1. UT Southwestern Medical Center 2. Parkland Health and Hospital System 3. University of Michigan Investigators will prospectively compare the performance of dynamic contrast enhanced abbreviated MRI (AMRI) and contrast-enhanced ultrasound for early-stage HCC detection in patients with indeterminate liver nodules.
Description
Investigators will prospectively perform both abbreviated MRI and contrast-enhanced ultrasound in enrolled patients every 3-6 months. Contrast-enhanced ultrasound and abbreviated MRI will preferably be done the same day, although will be permitted to be completed within 30 days of each other. Abbreviated MRI and contrast-enhanced ultrasound will be performed every 3-6 months until HCC development, regression to LR-1 or LR-2 (i.e., definitely or likely benign, respectively), or end of follow-up at 24 months post-enrollment.
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Child A or B cirrhosis from any etiology with at least one ILN on 4-phase CT, contrast- enhanced MRI, or contrast enhanced US but without HCC at baseline. * Adults 18 years old and above Exclusion Criteria: * Patients post liver transplantation * Patients with concurrent or prior HCC (LR-5 or biopsy proven) * other liver cancer including cholangiocarcinoma * Patients with any active extra-hepatic malignancy * Patients with significant comorbidity and limited life expectancy, e.g., stage D congestive heart failure, in whom surveillance is not warranted are also excluded…
Interventions
- Diagnostic TestCEUS imaging
Contrast-enhanced ultrasound (CEUS)
- Diagnostic TestaMRI imaging
contrast enhanced abbreviated MRI (AMRI)
Locations (2)
- University of MichiganAnn Arbor, Michigan
- University of Texas Southwestern Medical CenterDallas, Texas