Investigating Age Dependence of Fibroblast and Extracellular Matrix Responses to Cross-linked Hyaluronic Acid Filler in Human Skin
University of Michigan
Summary
The purpose of the study is to investigate the impact of the injection of dermal filler on the quality of the skin dermal extracellular matrix in persons between the ages of 30-50 years. The quality of the dermal extracellular matrix will be assessed following injection of dermal filler compared to injection of saline vehicle.
Eligibility
- Age range
- 30–50 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Subjects must understand and sign the informed consent prior to participation * Subjects must be in generally good health * Subjects must be able and willing to comply with the requirements of the protocol Exclusion Criteria: * Pregnant, plan to become pregnant during the study, or are nursing a child. Participants will be asked to self-report pregnancy * Individuals with bleeding disorders * Tend to heal poorly or form very thick scars called keloids * Have a lidocaine sensitivity, including those with epilepsy, impaired cardiac conduction, severely impaired hepatic f…
Interventions
- DeviceRestylane-L
Using a small gauge metal hub needle, two injections of CL-HA dermal filler (Restylane-L) will be performed, each into a small area (approximately 2 x 2 cm) of the mid-dermis of a forearm of a subject. Each injection will be 0.5 cc in volume, and will be approximately 2 cm apart from each other
- DeviceVehicle
Two injections of vehicle will be performed in the same manner as Restylane-L and in the same forearm, totaling 4 injections. A plastic template will be used to track the location of the injections, relative to landmarks on the skin.
Location
- University of MichiganAnn Arbor, Michigan