Effect of Olanzapine on Opioid Craving and Misuse Among Patients Receiving Opioids for Cancer-related Pain: A Pilot Double-Blind, Randomized Control Trial
M.D. Anderson Cancer Center
Summary
To learn about the effectiveness of taking the antipsychotic medication olanzapine to help lower opioid craving.
Description
Primary Objective To determine the effect of olanzapine on opioid craving among patients receiving opioids for cancer pain (Opioid Craving Scale; Opioid Craving Visual Analogue Scale, change from baseline) Secondary Objective To determine the effect of olanzapine on opioid misuse among patients receiving opioids for cancer pain (Current Opioid Misuse Measure, change from baseline) Exploratory Objective * To estimate the effect of olanzapine and placebo on the amount of opioid use among patients receiving opioids for cancer pain (morphine equivalent daily dose) * To determine the effect of o…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: 1. Age 18 years or older 2. Diagnosis of cancer pain 3. Receiving long-term opioid therapy (≥ 7 days)32 4. Active use of opioids within the past 7 days 5. Opioid misuse behavior (COMM score ≥ 9/68) 6. Seen by a Supportive Care Clinic or Pain Clinic clinician 7. ECOG performance status ≥ 2/4 8. Ability to communicate in English 9. Ability to understand and the willingness to sign a written informed consent document. Exclusion Criteria: 1. Contraindications to, or allergic to, olanzapine 2. Current use of any antipsychotic medication (e.g. quetiapine, haloperidol, risperid…
Interventions
- DrugOlanzapine
Given by PO
- DrugOlanzapine
Given by PO
- DrugPlacebo
Given by PO
Location
- MD Anderson Cancer CenterHouston, Texas