Neural Circuit-Specific Mechanisms of Ketamine's Effect on Anhedonia and Anxiety in Depression Using Ultra-High Field 7-Tesla MRI

Inclusion Criteria: MDD Group * Male or female aged 18-65 years; * Ability for participant to comply with the requirements of the study as determined by the PI; * Capacity to provide informed consent; * Meets diagnostic criteria for current MDD according to the Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition (DSM-5); * In a current major depressive episode (MDE) of at least moderate severity according to DSM-5; * Women must be using a medically accepted reliable means of contraception (if using an oral contraceptive medication, they must also be using a barrier contracept…