Wayne State Warriors Marijuana Clinical Research Program: Cannabinoid Adjunct to Prolonged Exposure & Recovery
Wayne State University
Summary
The overall strategy is to recruit veterans with PTSD who report minimal current cannabis use but are interested in or considering therapeutic cannabis to manage mental health symptoms (anxiety, depression, PTSD and/or suicidality). The information gained from this study could lead to the development of new treatments for persons who suffer from post-traumatic stress disorder and maintain better mental health.
Description
The total time commitment estimated per participant 20 study visits. This is broken down below: Visit 1: Pre-Screening and informed Consent: During this visit the potential participant will learn about the study procedures and sign the informed consent documents. Also, during this visit a licensed clinician will administer the (CAPS-5). Visit 2: Physical Examination and Questionnaires: During this visit the participant will undergo a full physical examination conducted by a licensed medical professional. At this time, they will collect blood, urine, breathalyzer and saliva samples. Visit 3:…
Eligibility
- Age range
- 18–60 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Willing and able to consent to the study * Agree to comply with requirements and procedures * Veteran who has served in a branch of the US armed forces * Between ages 18-60 * Report using cannabis within the past three years but not more than twice in the past month * Exposure to Criterion A stressor defined by CAPS-5 and identified by Life Events Checklist-5 (LEC-5); trauma does not have to be related to combat or military service * Significant PTSD severity as indicated by CAPS-5 diagnosis and/or score \>= 25 of at least one month prior to study entry, PTSD is patient'…
Interventions
- DrugCannabidiol (CBD) only
Cannabis consisting of 2.5mg CBD and 0mg Delta-9-tetrahydrocannabinol (THC) is administered via smoking.
- DrugPlacebo only
Placebo is administered via smoking in the same way as active drugs. Placebo cannabis material obtained through National Institute of Drug Abuse (NIDA) contains 0mg THC and 0mg CBD
- DrugDelta-9-tetrahydrocannabinol (THC) only
Cannabis containing 2.5mg THC and 0mg CBD is administered via smoking.
- DrugTHC:CBD 1:1
Cannabis containing 2.5mg of THC and 2.5mg of CBD is administered via smoking.
Location
- Tolan Park Medical BuildingDetroit, Michigan