Stony Brook University
The aim of this study is to compare intravenous famotidine, an H2 receptor antagonist, and Maalox/ Mylanta, an oral antacid, in treatment of dyspepsia in the emergency department. The goal of this study is to reduce patients' pain based on the verbal numerical pain scale. The anticipated outcome is for pain levels in both groups to decrease. It is expected that antacids will improve symptoms more quickly and to a greater degree within an hour of taking medication based on the results of similar studies.
This study will be conducted in the Emergency Department at Stony Brook University Hospital. Investigators intend to enroll approximately 80 patients who present to the emergency department with dyspepsia symptoms. The patients will be randomized to one of two groups: one group will receive 20 mg of intravenous famotidine and the other will receive 30 ml of oral Maalox/ Mylanta. The verbal numeric pain score (VNP) will be used to measure pain at 0 minutes, 15 minutes, 30 minutes, 45 minutes, and 60 minutes after administration of the study drug. Pain severity assessments will be performed by a…
Inclusion Criteria: 1. Subject Age ≥ 18 years of age 2. Patient diagnosed with dyspepsia 3. Present at the ED with upper abdominal pain score of at least 3 Exclusion Criteria: 1. Hypersensitivity to an ingredient in Maalox/ Mylanta or Famotidine 2. Moderate to Severe Renal Insufficiency (precaution) 3. Kidney Failure 4. Pregnant or Nursing 5. Verbal pain score less than 3 6. Inability to tolerate oral medications 7. Bowel Obstruction 8. Proton pump inhibitor within 2 hours of study treatment
Patients in this group will receive 20mg IV Famotidine.
Patients in this group will receive 30 ml Maalox/ Mylanta.
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