The Effects of Psilocybin on Self-Focus and Self-Related Processing in Major Depressive Disorder

Sharmin Ghaznavi

Summary

This open-label functional Magnetic Resonance Imaging (fMRI) study will assess the effects of a single dose of psilocybin on rumination and the neural correlates of rumination in individuals with major depressive disorder.

Eligibility

Age range: 18–55 years
Sex: All
Healthy volunteers: No

Detailed criteria

Inclusion Criteria: 1. Must be able to sign the informed consent form (ICF). Participants will demonstrate capacity to provide informed consent by demonstrated understanding of the protocol and what their involvement in the study requires from them. 2. Be 18-55 years of age at screening. 3. At least moderate Major Depressive Disorder (MDD; single or recurrent episode as informed by Diagnostic and Statistical Manual Version 5 (DSM-V); if single episode, duration of ≥ 3 months and ≤ 3 years) based on clinical assessment and a structured clinical interview, the Mini International Neuropsychiatri…

Interventions

Drug
Psilocybin
COMP360 (Brand name of psilocybin to be used)

Location

Athinoula A. Martinos Center for Biomedical Imaging
Charlestown, Massachusetts
cnpcogneuro@mgh.harvard.edu

The Effects of Psilocybin on Self-Focus and Self-Related Processing in Major Depressive Disorder

Summary

Eligibility

Interventions

Location

Compensation

Run this study?

Details

Conditions