Gut Microbiome Studies in Patients With POEMS Syndrome and Other Plasma Cell Disorders
Mayo Clinic
Summary
A Study to Evaluate Gut Microbiome with POEMS Syndrome and Other Plasma Cell Disorders
Description
The characteristics and role of gut microbiome rare plasma cell disorders- POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, skin changes) and amyloid light-chain (AL) amyloidosis, have not been explored; and their pathophysiology is quite elusive. To help understand rare plasma cell disorders and its association with gut microbiome, the investigators will study the stool samples of newly diagnosed POEMS patients and AL amyloidosis and compare it with patients with newly diagnosed monoclonal gammopathy of undetermined significance and multiple myeloma as well as…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Diagnosed with POEMS syndrome (newly diagnosed or in remission) or with newly diagnosed multiple myeloma (MM), monoclonal gammopathy of undetermined significance (MGUS), amyloid light chain (AL) amyloidosis or healthy controls from their households Exclusion Criteria: * Age under 18 years * Pregnancy * Substance abuse * Antibiotics use or gastrointestinal endoscopy in the 3 months prior to the study participation * Chronic gastrointestinal disorder * Gastrointestinal surgeries in the past 2 years * Chemotherapy (including anti-plasma cell treatment and steroids) or rad…
Interventions
- OtherNon-interventional study (observational)
Participants undergo stool sample collection, complete surveys, and have their medical record reviewed on study.
Location
- Mayo Clinic in RochesterRochester, Minnesota