Indiana University
This is a prospective pilot study to evaluate the safety, tolerability and technical feasibility of utilizing carbon dioxide for assessing coronary blood flow in subjects with coronary artery disease.
The purpose of this study is to noninvasively assess changes in the heart's blood flow through inducing changes in the amount of carbon dioxide in the participant's blood and having them breathe various combinations of carbon dioxide and oxygen.
Inclusion Criteria: 1. Adults \> 18 years of age 2. Clinically stable individuals with suspected or known coronary artery disease (CAD) 3. The SPECT/PET study indicates at least a mild to moderate myocardial ischemia (\>5-9%) or fractional-flow-reserve (FFR) of \<0.75. Exclusion Criteria: 1. Prior myocardial infarction by clinical history (subjects with prior coronary revascularization without myocardial infarction will not be excluded) 2. Hypotension (systolic blood pressure \< 100 mmHg) 3. Significant non-coronary cardiac disease (e.g., valvular abnormality, or cardiomyopathy, etc.) 4. In…
RespirAct device-based computer-controlled gas delivery at different concentrations as per protocol
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