Long-term Risk of Recurrent Cervical Artery Dissection After Pregnancy (LONG-RECAP Study)
University Hospital, Basel, Switzerland
Summary
Primary objective: To determine whether pregnancy increases the risk of recurrent CeAD and delayed stroke in women with prior CeAD based on long-term data. Methods: Multicentric, observational case-control study based on pooled individual patient data from several stroke centers. Primary endpoint: Primary composite outcome measure includes the following outcomes: (i) occurrence of recurrent CeAD, (ii) occurrence of ischemic or hemorrhagic stroke, (iii) death.
Description
Background: Cervical artery dissection (CeAD) is a leading cause of stroke in women of childbearing age. Among the population with an initial CeAD, about 9% show a recurrence event (a range from 0 to 25% has been reported). Recurrence of CeAD can occur for several years after the initial event. CeAD has been shown to occur in association with pregnancy, and the postpartum period, yet it remains unclear whether pregnancy increases the risk of recurrence or delayed stroke. Previous studies on this subject are either based on small sample sizes or lack long-term data. Objective: The investigator…
Eligibility
- Age range
- 18+ years
- Sex
- Female
- Healthy volunteers
- No
Inclusion Criteria: * female * prior symptomatic cervical artery dissection (= index CeAD) * at least one long-term follow-up visit (at least 6 months after the initial event) * with information available on outcome events: * recurrent dissection * ischemic stroke * hemorrhagic stroke * functional outcome assessed by mRS score * with data on pregnancy after the initial event * at least 18 years old at the initial event Exclusion Criteria: * Male patients * Age \<18 years * No long-term follow-up available or long-term follow-up \< 6 months after initial event * No data on pregnancy after in…
Locations (12)
- University of UtahSalt Lake City, Utah
- University of VirginiaCharlottesville, Virginia
- Stroke Unit Sanatorio AllendeCórdoba
- Department of Neurology, Medical University of InnsbruckInnsbruck, Tyrol
- Helsinki University Central HospitalHelsinki
- Charité Universitätsmedizin, Centrum für SchlaganfallforschungBerlin