HOPE in Action Kidney Transplantation From Donors With HIV: Impact on Rejection and Long-Term Outcomes
Johns Hopkins University
Summary
This research is being done to better understand rejection in transplant recipients with HIV who receive kidneys from donors with vs without HIV.
Description
Previously, people with HIV in need of a transplant could only receive organs from a donor without HIV. However, in November 2013, the HIV Organ Policy Equity (HOPE) Act made it possible for people with HIV to receive organs from donors with HIV as a part of a research study. Over the last two decades, people with HIV have received organs from donors without HIV, and in general, these recipients have done well after transplant and still maintained control of their HIV. Over the last several years, people with HIV have received organs from donors with HIV, and in general, these recipients have…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Participant meets local criteria for kidney transplant. * Participant is able to understand and provide informed consent. * Participant has documented HIV infection by any licensed assay or documented history of detectable HIV-1 RNA. * Participant is ≥ 18 years old. * HIV-1 RNA \< 50 copies/mL. Viral blips between 50-400 copies will be allowed as long as there are not consecutive measurements \> 200 copies/mL. * Participant is not suffering from significant wasting (e.g. body mass index \<21) thought to be related to HIV disease. Exclusion Criteria: * Participant has p…
Interventions
- OtherHIV D+/R+
Receipt of kidney transplant from a deceased donor with HIV.
- OtherHIV D-/R+
Receipt of kidney transplant from a deceased donor without HIV.
Locations (13)
- University of Alabama at BirminghamBirmingham, Alabama
- University of California, Los AngelesLos Angeles, California
- University of California, San DiegoSan Diego, California
- University of California, San FranciscoSan Francisco, California
- Rush University Medical CenterChicago, Illinois
- Ochsner Clinic FoundationNew Orleans, Louisiana