University of Colorado, Denver
This study will compare the effectiveness of two different treatments for preventing infection from frostbite injuries. These two treatments are A) aloe vera and B) long-acting silver wound dressings. The investigators will also study the safety and effectiveness of Dalbavancin, an FDA approved antibiotic used for treating people who develop frostbite wound infections, as well as evaluate how frostbite damage to individuals' bodies may affect how fast their kidney clear drugs from their systems.
Inclusion Criteria: * All aims, aged ≥18 - \< 99 years old admitted to UCH Burn Center with frostbite injury * Aim 1: Admitted to UCH Burn Center with acute (within 4 days of cold exposure) frostbite injury * Aim 2: Admitted to UCH Burn center with a clinically confirmed or suspected infected frostbite wound Exclusion Criteria: * Pregnant patients * Prisoners * Anticipated death within 48 hours of admission * Inability to obtain consent from patient, legally authorized representative, or proxy * Aim 1:Patients admitted five days and later from frostbite injury. Patients who have a clinical…
Mepilex Transfer Ag
Dermaid Aloe Vera
1500mg IV dose
Arctuva estimate
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