Hypophysectomy by Stereotactic Radiosurgery for Cancer-Related Pain
M.D. Anderson Cancer Center
Summary
To learn if hypophysectomy (treatment of the pituitary gland) using a type of radiation treatment called stereotactic radiosurgery (SRS) can help to relieve cancer-related pain.
Description
Primary Objective: To determine the feasibility of enrollment and treatment of patients within MD Anderson Cancer Center with SRS hypophysectomy to plan future trials. Feasibility will be defined as completion of SRS hypophysectomy enrollment and treatment of the lead-in cohort (n=20 patients) within one year of trial activation. Secondary Objectives: To obtain estimates of the change from baseline over time after SRS hypophysectomy in participants with refractory cancer-related pain in the worst pain subscale of the Brief Pain Inventory (BPI) short form.57 To obtain estimates of the chang…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Age ≥ 18 years old on the day of signing informed consent and willing and able to sign a written informed consent. * English fluency in order to complete PROs and neurocognitive assessment * Pathologic or cytologic confirmation of malignancy. * Poorly controlled intractable nociceptive or mixed pain limiting function or quality of life. Participants must have exhausted or not a candidate for standard of care pain control measures such as opioids, injections/ablations, conventional radiation therapy, or surgical intervention with a curative intent and pain limiting functi…
Interventions
- DeviceStereotactic Radiosurgery
Given by Radiation Therapy
Location
- MD Anderson Cancer CenterHouston, Texas