Multimodality Deep Phenotyping of Postural Orthostatic Tachycardia Syndrome (POTS), Aim 1
University of Texas Southwestern Medical Center
Summary
This is an observational study to deeply phenotype the disorder of POTS using multiple testing modalities.
Description
This comprehensive multimodality deep phenotyping will improve the diagnostic approach, inform the development of new treatments, and allow the targeting of therapies to specific POTS patients. The investigators will further identify the diagnostic tools, biomarkers, and clinical outcome measures most relevant to defining the disorder in clinical practice. The specific aim is to (1) Define clinical POTS classifications from multimodal clinical and laboratory data, (2) address exercise tolerance in POTS using metabolomic assessments, (3) evaluate novel POTS-specific patient outcome measures an…
Eligibility
- Age range
- 14+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: POTS Patients * Age ≥ 14 years, able to provide informed consent (assent with parental consent for age \< 18) and comply with procedures * Meets consensus criteria for POTS: (1) sustained increase in heart rate ≥ 30 bpm above supine baseline within 10 min of quiet standing or upright tilt (≥ 40 bpm in individuals 12 to 19 years of age) OR sustained upright HR (heart rate) \>120 bpm, (2) absence of orthostatic hypotension, (3) symptoms with standing that improve with sitting or lying down, (4) resting supine heart rate \< 100 bpm, (5) orthostatic symptoms present for at le…
Interventions
- Diagnostic Testmultimodal diagnostic testing
Serological testing, cardiac MRI, skin biopsy, cardiovascular testing, blood volume measurements
Location
- UT Southwestern Medical CenterDallas, Texas