Electroencephalogram (EEG) Personalized Transcranial Magnetic Stimulation (eTMS) for Post-Traumatic Stress Disorder (PTSD)
Virginia Polytechnic Institute and State University
Summary
A battery of physiological and behavioral data will be collected before and after application of eTMS. Participants will be veterans or first responders diagnosed with PTSD. Study will be a double-blind, sham-controlled, parallel group, randomized clinical trial.
Description
Veterans and first responders diagnosed with PTSD will be studied to evaluate safety and efficacy of an EEG personalized TMS paradigm. All participants will undergo 2 days of extensive testing prior to eTMS application and 2 days of testing after. Testing will include MRI, OPM, EEG, behavioral tasks, questionnaires, and an EEG sleep study.
Eligibility
- Age range
- 18–65 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Veteran or first responder * diagnosed with post-traumatic stress disorder with PCL-5 cutoff of 31 or above Exclusion Criteria: * Claustrophobia * Contraindications to MRI * Pregnant * Uncontrolled medical, psychological, or neurological conditions * Unable to calculate EEG alpha frequency * History of ECT or rTMS * History of intracranial lesion or increased intracranial pressure * History of stroke * History of other neurologic conditions * Family history of epilepsy * Personal history of epilepsy * certain medications
Interventions
- DeviceElectroencephalogram personalized Transcranial Magnetic Stimulation (eTMS)
EEG is utilized to determine a personalized frequency to then apply TMS to the frontal lobe.
Location
- Fralin Biomedical Research InstituteRoanoke, Virginia