A Randomized, Double-Blind, Placebo-Controlled, Three-Arm Parallel Study to Investigate the Effects of a Dietary Supplement Containing N-trans-Caffeoyltyramine (NCT) and N-trans-Feruloyltyramine (NFT) on Body Fat Composition
Brightseed
Summary
The purpose of the current study is to examine the effects of a dietary supplement containing plant derived phenolics at two different dose levels in otherwise generally healthy adults with risk factors (high BMI at dyslipidemia and/or pre-diabetes) for body fat composition. The primary hypothesis is that supplementation with plant derived phenolics will decrease body fat composition compared to placebo.
Eligibility
- Age range
- 18–75 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: 1. Male or female, ≥18 years of age at visit 1 (week -1). 2. Body mass index (BMI) of ≥28.0 kg/m2 to \<35.0 kg/m2 at visit 1 (week -1). 3. At least one of the following comorbidities based on blood draws at visit 1: * Dyslipidemia (any of the following) * Total-C ≥200 mg/dL * LDL-C ≥130 mg/dL * HDL-C ≤40 mg/dL * Triglycerides ≥150 mg/dL * Pre-diabetes o HbA1c ≥5.7 to ≤6.4% Stable use of medications allowed, where stable use is defined as the same dose for at least 90 d prior to visit1. 4. Non-user or former user (cessation ≥12 months) of tobacco…
Interventions
- OtherPlacebo treatment
Microcrystaline cellulose (MCC)
- Dietary SupplementPlant derived phenolics
Dietary supplement containing plant derived phenolics
Location
- Biofortis ResearchAddison, Illinois