Implementation of Adaptive DBS to Offset STN Dysregulation During Exercise and Reduce Exertion in Parkinson's Disease
University of Colorado, Denver
Summary
The investigators conduct a prospective study to evaluate the effects of exercise on Parkinson's Disease brain biomarkers detected with the PerceptTM PC neurostimulator.
Description
The investigators will conduct a prospective study to evaluate the effects of exercise on Local Field Potential biomarkers detected from the subthalmic nuclues in Parkinson's Disease with the PerceptTM PC neurostimulator. Subsequently, adaptive Deep Brain Stimulation applied in response to low beta peak (L-beta; 13-20Hz) will be performed to evaluate feasibility of whether aDBS can offset the effects of exacerbation of parkinsonism during exercise performance and recovery.
Eligibility
- Age range
- 20–70 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: Persons with PD who have a Medtronic DBS Sensight implant and a Percept IPG. \- Exclusion Criteria: Persons not meeting the above listed implant criteria Persons not meeting the age limit criteria Persons who are not able to complete the study exercise Persons not able to comprehend and consent to study participation.
Interventions
- DeviceaDBS
adaptive deep brain stimulation
Location
- University of ColoradoAurora, Colorado