NIDCD Otolaryngology Clinical Protocol Biospecimen Bank
National Institute on Deafness and Other Communication Disorders (NIDCD)
Summary
Background: Many disorders of the head and neck can affect a person s hearing; balance; smell; taste; swallowing; voice; or speech. These disorders include cancers and genetic and inflammatory diseases. To find better ways to diagnose and treat these disorders, researchers need to study tissues and other biological samples from people who have them. Objective: To collect biological samples for a repository that will be used for research. Eligibility: People of any age with a disorder of the head and neck that requires the taking of biological samples. The conditions may be any that affect hearing; balance; smell; taste; swallowing; voice; or speech. Design: Part 1: Participants will give permission for their leftover tissue samples to be used for research. These are tissue samples from the head and neck that were collected in the course of routine tests and care or other research studies. Information on each participant s age, diagnosis, and previous treatments will also be collected. Part 2: Some participants may be asked for more samples. All those aged 3 years or older will have a physical exam. They will provide blood and saliva samples. A cotton swab or brush will be used to collect cells from the inside of the cheek. Participants 18 years or older may have additional tests. They may provide nasal secretions: A piece of gelfoam or a sponge will be placed in the nose to soak up secretions for 5 to 10 minutes. They may have biopsies: Small samples of tissue will be cut from the skin and the tissue lining the mouth. Samples may be used for genetic testing.
Description
Study Description: National Institute on Deafness and Other Communication Disorders (NIDCD) investigators are studying the natural history and treatment of diverse conditions affecting hearing, balance, smell, taste, voice, speech and language at the National Institutes of Health (NIH). These studies require the collection of biospecimens for research purposes. Objectives: Primary: To create a biorepository of diseased and normal tissue specimens for research purposes. The samples will be obtained: * From surgical waste materials from participants of all ages in NIH protocols who have hea…
Eligibility
- Age range
- 3–99 years
- Sex
- All
- Healthy volunteers
- No
* INCLUSION CRITERIA In order to be eligible to participate in this study, an individual must meet all of the following criteria: * Ability to provide their own consent, or for minors, a parent or guardian is able to consent on their behalf. * Ability of subject (or Legally Authorized Representative (LAR) to understand and the willingness to sign a written informed consent document. * Have a hearing, balance, smell, taste, voice, speech or language condition for which the subject is under clinical care or research purposes under a separate Review Board (IRB) approved protocol; OR be a health…
Location
- National Institutes of Health Clinical CenterBethesda, Maryland