Oxidative Stress and Harmful Constituent Levels Associated With Little Cigars
Milton S. Hershey Medical Center
Summary
Determine the effects of little cigars on human exposure to tobacco smoke oxidants. In a balanced randomized cross-over study design in cigarette smokers, subjects will be assigned to 3 exposure groups. These include a high oxidant little cigar exposure condition, a low oxidant little cigar exposure condition, and their usual cigarette. Biological samples will be collected before and after product usage.
Description
Exhaled breath condensate samples will be collected at pre-product usage, post-product usage, 30, and 60 minutes. Samples will be analyzed for levels of oxidant markers including 8-isoprostanes, 8-OHdG acrolein adducts and C-reactive protein. Exhaled breath samples will be collected at pre-product usage and post-product usage. Samples will be analyzed for levels of oxidant markers in Volitive Organic Compound (VOC) profiles. Blood samples will be collected at pre-product usage and post-product usage. Samples will be analyzed nicotine, 8-isoprostane and other oxidative makers of stress. Bucc…
Eligibility
- Age range
- 21–65 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: 1. Aged 21 - 65 years old 2. Daily cigarette smoker (\>= 1 cigarette per day); 3. Smoke regular, filtered cigarettes or machine rolled cigarettes with a filter 4. No current or past use of Little Cigars 5. All other forms of nicotine must be used \<6 days out of the past 30 days. 6. Able to read and write in English 7. No serious cigarette smoking quit attempt or use of any FDA-approved smoking cessation medication in the prior 30 days 8. No plan to quitting smoking in the next 3 months Exclusion Criteria: 1. Women who are pregnant and/or nursing or trying to become preg…
Interventions
- OtherHigh Oxidant Little Cigar
Subjects will be given a high oxidant little cigar to use for outcome measure data collection in the lab before and after product usage.
- OtherLow Oxidant Little Cigar
Subjects will be given a low oxidant little cigar to use for outcome measure data collection in the lab before and after product usage.
- OtherUsual Cigarette
Subjects will use their own cigarette for outcome measure data collection in the lab before and after product usage.
Location
- Penn State College of MedicineHershey, Pennsylvania