The Effect of Protein Supplementation on Muscle Atrophy After ACL Reconstruction
The Methodist Hospital Research Institute
Summary
The purpose of the study is to assess the longitudinal post-operative care effects of protein supplementation on muscle atrophy in the post-operative period following ACL reconstruction. The main outcome will be muscle size/mass as measured using dual energy x-ray absorptiometry (DEXA) scanning. The primary objective is to assess for any beneficial impact of protein supplementation, with implications of standardizing a recommended protocol for protein supplementation after ACL reconstruction. Secondary outcomes will be to evaluate the survey data from the KOOS JR and Tampa Scale surveys, as well as functional measures recorded during physical therapy.
Description
This study is designed to evaluate non-interventional longitudinal post-operative clinical improvement. The proposed study is a randomized non-interventional, double blind study. Subjects will include patients age 16 to 40 undergoing primary ACL reconstruction for an acute ACL tear. Demographic information including age, sex, BMI, and sport participation will be obtained from patients at the time of recruitment. Subjects will be randomized to one of three categories: 1)placebo, 2)protein supplementation, or 3)protein supplementation with amino acids. The probability is is a 1 in 3 chance to b…
Eligibility
- Age range
- 16–40 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Subjects will include patients age 16 to 40 undergoing primary ACL reconstruction for an acute ACL tear with the PI or Sub-investigators Exclusion Criteria: * Subjects will not be included if they meet one of the following criteria * History of meniscectomy or meniscus repair * Obesity (BMI\>35) * Diabetes * Cardiovascular, renal, liver or pulmonary disease * Active infections * Cancer (current or treated within the past 2 years) or coagulation disorder * Rapid weight change within the past year * Physically unable to participate in the intervention…
Interventions
- Dietary SupplementWhey protein isolate
25g of whey protein isolate
- Dietary SupplementProtein + BAA
* Protein drink - 25g of whey protein isolate * Amino Acid Blend - 7g of protein (4g Leucine, 1g iso leucine, 1g valine, 1g arginine)
- Dietary SupplementPlacebo
• isocaloric-matched (25g) maltodextrin supplement
Location
- Houston MethodistHouston, Texas