Seattle Spatial Transcriptomic Research in Inflammatory Bowel Disease Evaluation
Seattle Children's Hospital
Summary
This is a prospective observational study collecting long-term clinical data and samples for research in pediatric inflammatory bowel disease (IBD) patients with gut inflammation and a control cohort of pediatric patients with disorders of the brain-gut interactions (DBGI) with no detectable gut inflammation.
Description
Research procedures will coincide with clinical visits at institutional standards. As part of their clinical disease evaluation, participants will have blood, stool, and tissue collected as indicated by their disease course. Additional research samples or data will be collected during these visits. Participants will be asked to collect urine samples specifically for research.
Eligibility
- Age range
- 6–21 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Suspected diagnosis of CD (Crohn's Disease), UC (Ulcerative Colitis) or Indeterminate colitis (IC) Exclusion Criteria: * Evidence of Other Complicating Medical Issues: * Other serious medical conditions, such as neurological, liver, kidney, or systemic disease * Pregnancy * Tobacco, alcohol, or illicit drug abuse
Interventions
- Diagnostic TestEsophagogastroduodenoscopy (EGD) with biopsy
Esophagogastroduodenoscopy (EGD) is a test procedure to examine the lining of the esophagus, stomach, and first part of the small intestine.
- Diagnostic TestColonoscopy w/ biopsy
Colonoscopy is a test procedure to examine the lining of the different portions of the large intestine: cecum, colon, rectum, and anal canal.
Location
- Seattle Children's HospitalSeattle, Washington