University of Rochester
Oral disulfiram (Antabuse®) has been shown to improve image-forming vision in animal models with retinal degeneration due to its ability to decrease Retinoic Acid synthesis and consequently reduce hyperactivity in the inner retina. The investigator will aim to evaluate the impact of oral disulfiram on the vision of patients with retinal degeneration who are being treated with the drug in the management of their concurrent alcohol use disorder.
Inclusion Criteria: * All sexes, 18 years and older. * Participants must speak English, understand, and sign the informed consent document. * Stated willingness to comply with all study procedures and availability for the duration of the study. * In good general health as evidenced by medical history and with a clinical diagnosis of inherited retinal dystrophy or dry-AMD. * Best Corrected Visual Acuity (BCVA) of 20/20 (with constriction or other defects of Goldmann visual field) to Light Perception in the better eye. * Intact inner nuclear layer, inner plexiform, and ganglion cell layer on ma…
250 mg/day
Arctuva estimate
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