Ultrasound Imaging for the Assessment of Lower Urinary Tract Symptoms
University of Wisconsin, Madison
Summary
The purpose of this research is to develop an ultrasound (US) based urodynamics (UDS) evaluation of voiding based on successful magnetic resonance imaging (MRI)-UDS evaluation. Both US and MRI are non-invasive imaging techniques, but US is a more cost-effective and widely available technology. 80 participants will be enrolled and will be on study for up to 2.5 hours (1.5 hour MRI and 1 hour US).
Description
The MRI - UDS technique provides voiding flow rates and bladder pressures which can be used to calculate the widely used metrics of obstruction (bladder outlet obstruction index, BOOI) and contractility (bladder contractility index, BCI). In a preliminary study, values for maximum flow (Qmax) and detrusor pressure at maximum flow (PdetQmax) were obtained from MRI-UDS for patients with BPH/LUTS. These results closely correlated with multichannel urodynamics (MCUD). Men with BPH/LUTS and age-matched controls will undergo a comprehensive protocol of dynamic MRI, 3D ultrasound and multi-channel u…
Eligibility
- Age range
- 18–80 years
- Sex
- Male
- Healthy volunteers
- Yes
Inclusion Criteria: Patients with BPH/LUTS * Age 18-80 years old * Diagnosed with BPH/LUTS with or without obstruction Exclusion Criteria: * Patients with contraindication to MRI and/or GBCA contrast agent. Diabetic subjects will not receive contrast. * History of overt neurologic disease other than diabetic neuropathy, urinary tract infection within the last 4 weeks or recent history of urinary retention (within the last 4 weeks). Inclusion Criteria: Healthy Volunteers \- Age 18-80 years old not experiencing any symptoms consistent with LUTS Exclusion Criteria: * Patients with contrain…
Interventions
- DeviceMRI-UDS; US-UDS; MCUD
Imaging procedures will include a comprehensive protocol of dynamic MRI, 3D ultrasound and MCUD to evaluate and validate this entirely novel methodology.
Location
- University of WisconsinMadison, Wisconsin