Feasibility and Efficacy of a Well-Formulated Ketogenic Diet in Delaying Progression of Polycystic Kidney Disease in Patients at Risk for Rapid Progression

Summary

This is a prospective study to determine ketogenic diet effect on htTKV, GFR, microalbuminuria. This is a single-center study of 20 patients with ADPKD and deemed high risk for progression to ESRD. This determined by combination of features of ADPKD and htTKV as assessed by prior computed tomography (CT) or MRI. Patients will be recruited from the Polycystic Kidney Disease (PKD) Clinic at Ohio State University Wexner Medical Center. Enrolled patients will have MRI for htTKV, urinary studies, blood tests at baseline, 6 months, and 52 weeks. Blood for GFR will be assessed three times over the course of the study including baseline, 6 months, and 1 year. Participants will follow ketogenic diet for 52 weeks. Investigatory diet team will manage the ketogenic diet.

Eligibility

Age range

18–65 years

Sex

All

Healthy volunteers

No

Interventions

• Other
  Ketogenic Diet

  The diet intervention will start after all baseline testing is complete

• Biological
  Ketone/Glucose Monitoring

  KetoMojo hand-held glucometer will be used daily to monitor dietary intervention adherence.

• Biological
  CGM/CKM

  Continuous Ketone/Glucose Monitor will be applied at the start of Test Day 1. The sensor will be checked by the study team at each test day and will be removed and replaced by a fresh sensor at \~2- week intervals during the study. The sensor will be removed at the end of the final test day.

• Biological
  Blood Draw

  Blood samples will be collected according to the schedule in Figure 1

• Other
  Body Composition

  DEXA Scanning will be done pre-, mid-, and post- intervention.

• Other
  Change in glomerular filtration rate (mg/mmol) via magnetic resonance imaging (MRI) .

Location