Oxalobacter Formigenes Colonization in Calcium Oxalate Kidney Stone Formers

Summary

The goal of this trial is to test if colonization with the gut bacteria Oxalobacter formigenes leads to a reduction in urinary oxalate excretion in patients with calcium oxalate kidney stone disease. The study will recruit adult participants with a history of calcium oxalate kidney stones who are not colonized with Oxalobacter formigenes. Participants will * ingest fixed diets containing low and moderately high amounts of oxalate for 4 days at a time * collect urine, blood and stool samples during the fixed diets * ingest a preparation of live Oxalobacter formigenes to induce colonization with Oxalobacter formigenes

Description

Eligibility

Age range

18–70 years

Sex

All

Healthy volunteers

No

Interventions

• Dietary Supplement
  Low oxalate fixed diets pre-colonization

  4 days of fixed eucaloric diet with low oxalate (\< 60 mg/day), normal calcium (600-1000 mg/day)

• Dietary Supplement
  Moderately high oxalate fixed diets pre-colonization

  4 days of fixed eucaloric diet with moderately high oxalate (250-300 mg/day), normal calcium (600-1000 mg/day)

• Dietary Supplement
  Colonization with Oxalobacter formigenes

  Ingestion of live Oxalobacter formigenes

• Dietary Supplement
  Low oxalate fixed diets post-colonization

  4 days of fixed eucaloric diet with low oxalate (\< 60 mg/day), normal calcium (600-1000 mg/day)

• Dietary Supplement
  Moderately high oxalate fixed diets post-colonization

  4 days of fixed eucaloric diet with moderately high oxalate (250-300 mg/day), normal calcium (600-1000 mg/day)

Locations (2)