University of California, San Diego
To develop strategies to identify postpartum women at risk for adverse cardiovascular outcomes and provide them with preventative therapies.
The investigators will recruit and retain a diverse population of pregnant women who are high- and low-risk for hypertensive disorders of pregnancy/preeclampsia (HDP/PE) for longitudinal collection of phenotypic and environmental exposure measures and biosamples for integrative analysis of phenotypic, environmental, and multi-omic data to understand links between development of HDP/PE and associated fetal pathologies during pregnancy, as well as postpartum maternal health. Participation in the study will begin no later than the second trimester of pregnancy (enrollment by 24 weeks of gestation…
Inclusion Criteria: * Pregnant women 18 years of age to 50 years of age * 10-24 weeks gestation at time of enrollment * Singleton pregnancy * Planning to deliver at a study site (UCSD or VUMC) Exclusion Criteria: * Inability to give informed consent * Intrauterine fetal demise * Fetal genetic or structural anomaly * Institutionalization for psychiatric disorder, mental deficiency or incarcerated * Active or history of malignancy requiring major surgery or systemic chemotherapy * Multi-fetal gestation or a twin demise at any gestational age * Known maternal or fetal chromosomal anomalies * P…
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