Post-Pandemic Genomic Epidemiology of Pneumococcal Carriage Among Children and Adults in the General US Population
University of Central Florida
Summary
The PI propose to conduct a genomic epidemiology study of pneumococcal carriage among children and adults in a large metropolitan city. These data will allow PI to assess the post-pandemic population structure, investigate the phylogenetic relationship between isolates from children and adults, and compare pneumococcal populations across diverse geographic areas.
Description
The SARS-CoV-2 pandemic profoundly impacted human health directly and indirectly. As such, elucidating pre- and post-pandemic trends in the epidemiology and population genomics of human respiratory pathogens including those such as the bacteria Streptococcus pneumoniae, a human commensal and the causative agent of invasive pneumococcal disease (IPD), merits study. Nasopharyngeal samples will be processed at the PIs Laboratory to identify S. pneumoniae. If present, the isolate will undergo bacterial whole genome sequencings and population dynamic analysis. Carriage prevalence and serotype comp…
Eligibility
- Age range
- 0+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * Children, ages 7 to 59 months (less than 5 years) * Adults, ages 50 and older * Ability to provide informed consent (from parents for children participants) * ability to read and speak in English * Agree to comply with study procedures (complete online data questionnaire and provide a nasopharyngeal collection). Exclusion Criteria: * Have been on an antibiotic in the last 2 weeks * Have a respiratory infection that would make an nasopharyngeal collection improbable * Have underlying developmental or chronic conditions impacting immune or respiratory function (e.g., imm…
Location
- University of Central FloridaOrlando, Florida