Allogeneic Valve Transplantation
Boston Children's Hospital
Summary
Valves will be taken from hearts donated by organ donors, and implanted into patients who need a new heart valve.
Description
Heart valves in children and young adults may need replacement or repair. In many children the options for heart valve replacement do not grow as the child grows. A transplanted valve may have the option to grow with time and may reduce the need for multiple operations over a lifetime. This trial will study the outcomes of heartfelt transplant in children and young adults undergoing this procedure. The study will look at outcomes of valve transplant and any potential side effects.
Eligibility
- Age range
- 0–50 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria * Patients requiring aortic, pulmonary, mitral or tricuspid valve replacement. * Pediatric patients 30 days or older and \< 18 years, and adult patients 18-50 yrs. o Particularly patients with significant growth potential * Insufficient options are available for valve replacement o Patients at risk of immunogenic bio-prosthetic valve failure * Discussion with patient /family - option for durable valve rather than traditional prosthesis * ABO compatible * Patient and family able to travel to BCH within 48 hour time frame or within our organ procurement organization * P…
Interventions
- ProcedureValve transplant
Heart valves from an organ donor will be transplanted into recipient
Location
- Boston Children's HospitalBoston, Massachusetts