Prospective Multicenter Research on Donor and Recipient Management Strategies to Improve Lung Transplant Outcomes: PROMISE-Lung Study
Duke University
Summary
This project aims to collect detailed clinical data, blood samples, and patient-reported outcomes from 2,600 lung transplant candidates, donors, and recipients at Lung Transplant Centers. The goal is to create a robust resource for various research objectives, including studying the impact of variations in donor and medical practices on clinical outcomes. The project also seeks to identify serum biomarkers associated with or predictive of specific post-transplant complications and conditions.
Description
This is an observational, prospective, multicenter cohort study of 2,600 lung transplant donors and adult (18 years and older) lung transplant candidates and recipients that will collect longitudinal clinical data, and serial biological (blood) specimens and PROs to support a broad range of clinical and translational future research. Data and biospecimens will be rigorously collected and monitored to ensure high quality future studies that will address unmet needs and optimal management at each stage of the transplant journey from listing, to donor selection, to postoperative management. Subje…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: 1. Able to understand and provide informed consent 2. ≥ 18 years of age at the time of written informed consent 3. Anticipated listing or listed for a single or bilateral cadaveric donor lung transplant or having received a lung transplant within 30 days * Participants undergoing repeat lung transplantation or multi-organ transplantation are eligible if they meet the inclusion/exclusion criteria. Exclusion Criteria: 1. Unwillingness of a participant or legally authorized representative (LAR) to give written informed consent or comply with study protocol 2. Pregnancy…
Locations (17)
- University of California Los AngelesLos Angeles, California
- University of California at San FranciscoSan Francisco, California
- University of MiamiMiami, Florida
- Johns Hopkins UniversityBaltimore, Maryland
- Brigham and Womens HospitalBoston, Massachusetts
- University of MichiganAnn Arbor, Michigan