Occlusion Pressure at 100 Msec, TCe ( Expiratory Time Constant ), Stress Energy Density, Mechanical Power, Ventilatory Ratio and C20/Cdyn in Predicting Outcomes in Patients With Moderately Severe ARDS, Who Are on Mechanical Ventilation
CentraCare
Summary
This is a single-centre prospective observational study aimed to determine if Pocc (occlusion pressure at 100 msec), TCe ( Expiratory time constant ), Mechanical Stress power, Ventilatory ratio and C20/Cdyn would predict outcomes in patients with moderately severe ARDS (Acute respiratory distress syndrome), who are on mechanical ventilation
Description
Severe ARDS is characterized by significant lung heterogeneity with areas of collapse, consolidation and normal lung parenchyma. Institution of mechanical ventilation may result in Ventilation-induced lung injury because of significant heterogeneity with associated volutrauma, atelectrauma and barotrauma. Underassistance results in persistent atelectasis and resultant diffusion abnormalities and over-assistance causes ventilator-associated lung injury. Mechanical power and driving pressure have been demonstrated to predict mortality in patients with Acute respiratory distress syndrome who ar…
Eligibility
- Age range
- 19–80 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Patients with Acute respiratory failure needing mechanical ventilation * Diagnosis of Severe ARDS with severity: PF ratio \< 150, with PEEP/CPAP \> 5 Exclusion Criteria: * r2 \< 0.95, monitored on the ventilator * Expiratory flow that is not first-order or non-exponential decay * Patients with Nor-epinephrine requirements \> 0.1 mcg/kg/min within 2 hours of intubation * Patients requiring ECMO ( Extracorporeal membrane oxygenation) * Patients with COPD or pulmonary fibrosis with a premorbid FEV1 \< 1.5 L * Severe atherosclerotic vascular disease * Patients with a chest…
Interventions
- Diagnostic TestPoccl, Time constant, driving pressure
Ventilatory parameters
Location
- St Cloud HospitalSaint Cloud, Minnesota