Identifying the Neural Basis of Depression in Parkinson's Disease
Yale University
Summary
The goal of this observational study is to identify targetable neural substrates of depression in Parkinson's Disease for the first time in people with Parkinson's between the ages of 40 and 80, who are experiencing symptoms of depression.
Description
This study will compare people with Parkinson's Disease and depression to individuals with Parkinson's Disease without Major Depressive Disorder, Major Depressive Disorder with no Parkinson's, and Healthy Controls. Up to 30 participants will be recruited and enrolled for each of these 4 groups. Participants will be asked to complete one PET and one MRI scan along with study assessments. Once screening and consent is completed, participants will be scheduled for PET and MRI scans. The total duration for participants in this study is 7 hours, including the screening visit and then one additional…
Eligibility
- Age range
- 40–80 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: 1. Age 40-80. 2. For women of reproductive potential, a negative pregnancy test at screening and scanning 3. For PD patients, clinical diagnosis of PD, able to consent and tolerate PET procedures 4. For PD depression patients - at least moderate symptom severity as determined by at least 15 on the MADRS, which has shown maximum discrimination between depressed and non-depressed PD patients. 5. For dPD patients undergoing ketamine, abstinence from drugs of abuse, other than alcohol, cannabis, nicotine and caffeine for the duration of the study. Patients with substance use d…
Interventions
- Radiation11C-UCB-J
Radiotracer for imaging
- Drugketamine hydrochloride
There will be a small subset (opt-in) who will receive a single dose of ketamine to determine the ability of ketamine to target these mechanisms and initiate an associated antidepressant response. If the participant is opting into the ketamine arm, the investigators will ask them to come in for one single-dose of ketamine and complete another PET and MRI scan post-ketamine treatment.
Location
- Yale UniversityNew Haven, Connecticut