Kinematic and Neural Dynamics of Postural Instability in Parkinson's Disease
VA Office of Research and Development
Summary
Balance problems and falls are among the most common complaints in Veterans with Parkinson's Disease (PD), but there are no effective treatments and the ability to measure balance and falls remains quite poor. This study uses wearable sensors to measure balance and uses deep brain stimulation electrodes to measure electric signals from the brain in Veterans with PD. The investigators hope to use this data to better understand the brain pathways underlying balance problems in PD so that new treatments to improve balance and reduce falls in Veterans with PD can be designed.
Description
Parkinson's disease (PD) is a progressive neurodegenerative disorder that manifests with the cardinal motor signs of bradykinesia, rigidity, tremor and postural instability (PI). Postural instability is a major cause of falls and as the disease process progresses, the most common patient complaints center on gait and balance difficulties leading to falls. Falls are the most common reason for hospitalization in PD patients, impose a significant economic burden to the US healthcare system and are a major cause of diminished quality of life, reduced mobility, disability and death. Both clinical a…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: Aims 1 and 2 Inclusion criteria: * All Veterans with a clinical diagnosis of Parkinson's disease as made by their treating neurologist in Hoehn and Yahr stage 2-3 with the ability to give informed consent will be considered for possible participation in this study. * Veterans cannot be past stage 3 as our measures depend on physical independence and fall risk prediction is less useful after stage 3. * Capacity to consent will be assessed with the University of California, San Diego Brief Assessment of Capacity to Consent (UBACC). * A score of less than 14.5 will be use…
Location
- Minneapolis VA Health Care System, Minneapolis, MNMinneapolis, Minnesota