Validation of MRI, CT and Pulmonary Function Tests for Early Detection of Chronic Lung Allograft Dysfunction

Summary

This studies purpose is to confirm the efficacy and efficiency of using OE-MRI and MRI with hyperpolarized gas techniques and Iodinated contrast CT scan, this will enhance understanding of CLAD pathophysiology. Moreover, this project is foundational to performing additional studies to establish if novel MRI imaging can serve as an objective confirmatory diagnostic tool for CLAD in post-transplant patients.

Description

Eligibility

Age range

18–80 years

Sex

All

Healthy volunteers

Yes

Interventions

• Diagnostic Test
  Spirometry

  Spirometry measures lung function, specifically the amount and/or speed of air that can be inhaled and exhaled.

• Diagnostic Test
  Contrast Lung Computed Tomography (CT) Scan

  CT scan of the lungs using contrast

• Diagnostic Test
  Oxygen enhanced magnetic resonance imaging (OE-MRI) Scan

  MRI will be taken while subject is lying on their back breathing 100% oxygen.

• Drug
  129Xe MRI scans

  MRI will be taken while subject is lying on their back breathing room oxygen and taking a breath of 129Xe and holding it for a few seconds.

Location