Laureate Institute for Brain Research, Inc.
In this project, the investigators examine behavior and associated brain activity during explore-exploit decision-making tasks performed pre- and post-modulation of affective state using autobiographical memory recall. The investigators hypothesize that a positive memory recall will reduce negative affective state, reduce explore-exploit biases and normalize the associated brain activity. The investigators propose a randomized double-blind, sham-controlled trial of positive autobiographical memory recall with 80 adults (n=40 per arm) with methamphetamine use disorder (MUD) currently involved in abstinence only treatment centers.
The growing epidemic of methamphetamine use disorder (MUD) is a significant burden on public health with surging overdose deaths, high likelihood of relapse, and current lack of approved medication to treat the disorder. When it comes to decision-making, individuals with MUD often prioritize drug over non-drug rewards despite negative life consequences; in addition, they may not sufficiently "explore" all available choices to "exploit" the best one (in other words, make the optimal choice leading to positive consequences). Therefore, the "explore-exploit" trade-off is often dysfunctional in MU…
Inclusion Criteria: * Adults 18-65 years old * English proficiency as evaluated by language ability during screening * Past-year diagnosis of DSM-5 methamphetamine use disorder (MUD) confirmed by the MINI * Actively enrolled in treatment for substance use disorder. Exclusion Criteria: * Severe traumatic brain injury (as indicated by a score ≥3 on the Tulsa Head Injury Screen * Any medical condition interfering with the participation in the study as determined by medical screening * DSM-5 diagnosis of psychotic disorders, bipolar I disorder, or major depressive disorder with psychosis * fMRI…
Autobiographical memory recall designed to modulate mood and affective state by reminiscing about personal life events
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