Phase 2 Trial of Ulixertinib for Patients With Histiocytic Neoplasms
Memorial Sloan Kettering Cancer Center
Summary
The researchers are doing this study is to find out whether ulixertinib is an effective and safe treatment for people with histiocytic neoplasms.
Eligibility
- Age range
- 12+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Histologically confirmed histiocytic neoplasm or histologic findings consistent with histiocytic neoplasm with confirmatory radiologic or molecular findings. Pathologic examination can be performed at any of the enrolling institutions. This qualification is made because it is well known that biopsies of histiocytic neoplasms are variable and do not always demonstrate "typical" morphologic appearance with all of the classically described elements. As a result, histiocytic neoplasms are not exclusively pathologic diagnoses-rather, they are interpretations of histologic fin…
Interventions
- DrugUlixertinib
300 mg twice daily, for every 28-day cycle.
Locations (8)
- Mayo Clinic (Data Collection Only)Rochester, Minnesota
- Memorial Sloan Kettering Basking Ridge (Consent Only)Basking Ridge, New Jersey
- Memorial Sloan Kettering Monmouth (Limited Protocol Activities)Middletown, New Jersey
- Memorial Sloan Kettering Bergen (Consent Only)Montvale, New Jersey
- Memorial Sloan Kettering Suffolk-Commack (Consent Only)Commack, New York
- Memorial Sloan Kettering Westchester (Limited Protocol Activities)Harrison, New York