Impact of Early Aging and Menopause on the Vascular Responses to Hypoxia
University of Missouri-Columbia
Summary
The purpose of this study is to examine hypoxic vasodilation and the role of beta-adrenergic receptors in younger premenopausal, perimenopausal, and older postmenopausal women.
Eligibility
- Age range
- 18–70 years
- Sex
- Female
- Healthy volunteers
- Yes
Inclusion Criteria: * Female assigned at birth * Pre, peri- or post-menopausal * Healthy weight (BMI ≥18 and ≤30 kg/m2) Exclusion Criteria: * Male (assigned at birth) * Pregnancy, breastfeeding * Use of hormone replacement therapies * Hysterectomy * Body mass index \>30 kg/m2 * Diagnosed sleep apnea * Current smoking/Nicotine/Drug use * Nerve/neurologic disease * Cardiovascular, hepatic, renal, respiratory disease * Blood pressure ≥140/90 mmHg * Diabetes, Polycystic ovarian syndrome * Communication barriers * Prescription medications * Malignant cancer
Interventions
- DrugPlacebo
Participants will receive a placebo in pill form.
- DrugPropranolol
Participants will receive oral propranolol (1 mg/kg).
- DrugGemtesa
Participants will receive oral gemtesa (75 mg).
Location
- University of Missouri-ColumbiaColumbia, Missouri