Dartmouth-Hitchcock Medical Center
This is a prospective, placebo-controlled, double-blinded randomized study of self-administered auditory intervention in a naturalistic home environment.
This study aims to replicate and extend findings from prior electrophysiological studies that demonstrated a reduction in epileptiform discharges and seizures in patients living with drug-resistant (medications are not effective) epilepsy after listening to specific music. It is believed to be the first study to examine the effect of daily, self-administered musical stimuli in reduction of epileptiform event detections over days to weeks. The study will enroll a cohort of patients already implanted with NeuroPace Responsive Neurostimulator (RNS) device to treat their epilepsy. This device use…
Inclusion Criteria: * Adults with medication-refractory focal epilepsy who have undergone RNS implantation at least six months prior and are in the judgement of the treating physician on a stable RNS regimen in terms of stimulation * Willing to attend all study visits and complete all required study procedures * Access to private or public wireless data service at regular intervals * Access to personal mobile device Exclusion Criteria: * Documentation of a musicogenic, or auditory-triggered focal seizure semiology * Participant is unable to reasonably participate in study tasks as determine…
Participants will be asked to listen to Music A on their personal device daily, at a time most convenient for them.
Participants will be asked to listen to music B on their personal device daily, at a time most convenient for them.
Participants will be asked to listen to music C on their personal device daily, at a time most convenient for them.
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