The Effect of Sympathetic Modulation on Cerebral Vasospasm Secondary to Aneurysmal Subarachnoid Hemorrhage
University of Alabama at Birmingham
Summary
The purpose of the study is to see that in addition to existing therapy, how well an additional procedure named spinal cord stimulation might reduce blood vessel spasm from aneurysm rupture.
Description
The Investigators' overarching hypothesis is that sympathetic innervation plays a substantial role in conferring cerebral vasospasm (CVS) risk to aneurysmal subarachnoid hemorrhage (aSAH) patients and is associated with severity of clinical features and outcomes. Specifically, the Investigators surmise that central (hypothalamic) and local (arterial adventitia) sympathetic inputs are upregulated following SAH and integrate at the level of the neuromuscular junction to abnormally increase cerebrovascular tone. The long-term goal of this program is to use orthogonal approaches to undertake a com…
Eligibility
- Age range
- 18–65 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: 1. Provision of signed and dated informed consent form 2. Stated willingness to comply with all study procedures and availability for the duration of the study 3. Diagnosed with Fisher grade 3 or 4 aneurysmal subarachnoid hemorrhage (1) 4. Ability to undergo endovascular treatment of aneurysmal subarachnoid hemorrhage 5. For females of reproductive potential: Negative pregnancy test at time of treatment 6. Plan to undergo standard of care and follow-up Exclusion Criteria: 1. Medically unfit to undergo endovascular treatment (e.g., Hunt Hess grade 5) 2. Does not provide c…
Interventions
- DeviceVectris trial leads and stimulation
The electrode is placed into the epidural space using standard epidural placement techniques with paramedian approach. The initial electrode settings have been adopted from prior studies. Should any significant discomfort be elicited from the stimulation, first the amplitude will be decreased to an acceptable level. If an acceptable level of stimulation is unable to be found, the stimulation will be discontinued.
- DeviceSham
No electrode is placed.
Location
- University of Alabama at BirminghamBirmingham, Alabama