High-resolution Functional Imaging of Speech-induced Sensory Modulation
University of Pittsburgh
Summary
The goal of this research study is to learn how the brain areas that plan and control movement interact with the areas responsible for hearing and perceiving speech in healthy adults and people who have had cerebellar strokes. The main questions it aims to answer are: 1. What regions of the brain's sensory systems show changes in their activity related to speech? 2. To what extent do these regions help listeners detect and correct speech errors? 3. What is the role of the cerebellum (a part of the brain in the back of the head) in these activities? Participants will be asked to complete several experimental sessions involving behavioral speech and related tests and non-invasive brain imaging using electroencephalography (EEG) and functional magnetic resonance imaging (fMRI).
Description
This study aims to provide an integrated view of brain systems underlying predictive coding in speech with unprecedented detail using ultra-high field (7 Tesla) functional magnetic resonance imaging. The overall approach is a condition-intensive within-subjects design, with extensive sampling of individual participants, including a group who have had strokes impacting the cerebellum, across multiple sessions. Participants will be asked to complete up to 6 sessions. Passing a hearing assessment using standard audiological procedures, conducted at the start of the first session, is a requiremen…
Eligibility
- Age range
- 18+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: Cohort 1 (neurotypical adults): * Age 18-49 * Right-handed * Native English speaker Cohort 2 (people with cerebellar lesions): * Age 18 or older * Right-handed * Native English speaker * History of cerebellar stroke Cohort 3 (controls matched to Cohort 2) * Age 18 or older * Right-handed * Native English speaker Exclusion Criteria: Cohort 1 (neurotypical adults): * Presence of MRI risk factors: metal and/or electromagnetic devices (e.g., pacemakers, neurostimulators) in the body, previous shrapnel injuries, use of an intrauterine device containing metal, claustroph…
Interventions
- BehavioralNeural responses to speech functional localizer
Measuring speech-related brain activity using fMRI during a speech listening task.
- BehavioralNeural responses to silent articulation
Measuring speech-related brain activity using fMRI during a silent articulation task.
- BehavioralNeural responses to self vs. externally generated speech
Measuring speech-related brain activity using fMRI during self-generated vs. externally-generated speech.
- BehavioralEvent-related potentials for speech
Measuring electroencephalography (EEG) based evoked potentials for self vs. externally generated speech
- BehavioralNeural responses to induced speech errors
Measuring speech-related brain activity using fMRI during conditions that induce auditory speech errors.
Location
- University of PittsburghPittsburgh, Pennsylvania