Fluoroethyltyrosine for the Evaluation of Intracranial Neoplasm
Thomas Hope
Summary
This is a single center study investigating the use of Fluoroethyltyrosine (FET) in the detection of brain tumors. FET accumulates in malignant cells within intracranial neoplasms and can be used to detect recurrent disease and characterize grade of glial neoplasms.
Description
PRIMARY OBJECTIVES: 1. To determine if FET Positron Emission Tomography (PET) scan can differentiate between benign treatment-related changes and recurrence in comparison to pathology in population 1 with recurrent metastatic disease and high-grade gliomas. 2. To determine if FET PET scan can differentiate between low-grade and high-grade gliomas in population 2. SECONDARY OBJECTIVES: 1. To determine if FET PET scan can differentiate between benign treatment- related changes and recurrence in comparison to pathology or imaging follow-up in population 1. 2. To determine if FET PET scan can d…
Eligibility
- Age range
- 4+ years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Presence or suspicion of intracranial neoplasm in two populations: * Population 1: Participants after primary treatment (radiation therapy and/or surgery) with suspicion of recurrence on MRI. * Three sub-populations will be considered: * Recurrent metastatic lesions. * Recurrent high-grade gliomas (Grades 3 and 4). * Recurrent low-grade gliomas (Grade 2). * Population 2: Participants prior to primary treatment with planned biopsy or surgical resection. * Age \> 3 years. Participants in other clinical trials will be eligible for this study including p…
Interventions
- DrugFluorethyltyrosine (18-F)
Given intravenously (IV)
- ProcedurePositron Emission Tomography (PET)
Undergo Imaging Procedure
Location
- University of California, San FranciscoSan Francisco, California