Gamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant Depression
Texas A&M University
Summary
The core objective of this study is to enhance the translational potential of this electroencephalogram (EEG) biomarker by using ketamine(KET)-induced gamma potentiation as a prognostic marker of 4-week treatment outcome. Previous research focused exclusively on KET-induced gamma band potentiation (GBP) in the context of a single infusion. Our study design captures the clinical variation associated with real-world treatment resistant depression (TRD) patients and allows us to analyze the relative importance of GBP to antidepressant symptom reduction across the induction phase of treatment. If successful, it provides a compelling rationale for a larger prospective investigation of gamma dynamics as a moderator of outcome to varied TRD therapies which impact the balance of cortical excitation and inhibition.
Description
Treatment-resistant depression (TRD) is a significant public health issue and the leading cause of disability in young and middle-aged adults. Treatment of depression via the rapid acting modulation of neural circuitry is at a critical stage of development with strategies such as ketamine (KET) infusion, esketamine nasal spray, and intermittent theta burst stimulation making substantial progress. Determining the prognosis for an intervention, however, remains a challenge due to the lack of a central biomarker to indicate the potential receptiveness of the target system (glutamate) to modulatio…