CAUSAL: Cohort to Augment the Understanding of Sarcoma Survivorship Across the Lifespan
Vanderbilt-Ingram Cancer Center
Summary
This study evaluates the impact that a sarcoma diagnosis and treatment have had on patients over time.
Description
* To evaluate the incidence and prevalence and the impact of disease, treatment, sociodemographic and lifestyle contributors on adverse oncologic outcomes (lack of response, recurrence) and non- oncologic outcomes (physical and psychosocial function, financial toxicity, short and long-term organ toxicity) and mortality in the cohort. * To evaluate the role of drug metabolism and DNA repair genes via functional polymorphisms, known toxicity associated polymorphisms and genetically predicted gene expression levels, as well as polygenic risk scores, on treatment efficacy, cancer therapy-induced n…
Eligibility
- Age range
- Not specified
- Sex
- All
- Healthy volunteers
- Yes
Patients at any age with a history of sarcoma, with or without evidence of a persistent disease • For pediatric patients * Parent/primary caregiver of patient * Sibling of patient aged 8 years or older
Interventions
- OtherSurveys
Complete surveys
- OtherBlood Collection
Undergo blood collection
- OtherSaliva Collection
Undergo salvia collection
- OtherUrine Collection
Undergo urine collection
- OtherStool Collection
Undergo stool collection
- OtherTissue collection
Undergo tissue collection
- OtherPhysical Activity Monitoring
FitBit will be worn to track physical activity
Location
- Vanderbilt University/Ingram Cancer CenterNashville, Tennessee