University of California, San Francisco
This study will support the expansion of long-acting injectable antiretroviral therapy (LAI-ART) in non-clinical settings by developing, implementing, and evaluating a comprehensive, theory-informed training intervention to support the administration of LAI-ART by a trained layperson injector (e.g., friend, family, partner identified by a person living with HIV). This study will address barriers to LAI-ART uptake and persistence, enhance real-world effectiveness, and help close critical HIV care gaps.
There is high interest in long-acting injectable antiretroviral therapy (LAI-ART) among people with (PWH), with many conveniences for uptake and persistence. While LAI-ART eliminate the need for daily pill-taking and have the potential to help close critical gaps in HIV care, patients have expressed important barriers to effective implementation and concerns that frequent clinic visits can exacerbate stigma, increase the risk of unwanted disclosure, and lead to frequent disruptions in their daily lives. The need to travel to a clinic for injection visits multiple times throughout the year can…
Inclusion Criteria: PWH: * Age ≥18 years, patient receiving care at partnering clinical sites; * can identify a support person injector (i.e., family, friend, or partner) who is willing and able to provide injections; * has received at least the loading dose of cabotegravir/rilpivirine CAB/RPV (i.e., 600mg/900mg IM) without serious adverse events; * is virologically suppressed (HIV RNA \<50 copies/mL); * has no history of treatment failure; * has no known or suspected resistance to either RPV or CAB; * is interested in receiving home-based injections; is approved by their clinical team as a…
Curriculum to train Treatment Buddies, selected by the people with HIV, to administer LAI-ART at home with supervision of a Study Nurse.
People with HIV who continue to receive LAI-ART in clinic
Oral ART
Arctuva estimate
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