Online Interplay Between Deciding and Acting With Mild Cognitive Impairment
University of Delaware
Summary
The investigators aim to understand the interplay and neural structures involved with decision--making and movement for participants with mild cognitive impairment. Rapidly deciding and acting becomes bottlenecked with mild cognitive impairment and Alzheimer's, leading to detrimental outcomes such as falling and car crashes. The investigators work will have a tangible impact by discovering sensitive biomarkers to detect disease onset and pave the way for informed and effective neurorehabilitation.
Description
Mild cognitive impairment leads not only to impaired decision making, but also movement deficits that predict the development of Alzheimer's disease. Recent behavioral work has suggested a common mechanism that throttles the speed of both decisions and reaching movements, which is supported by converging neural evidence that finds an interac-tion between decision making and movement (motor) circuits. Yet it remains unknown how the interplay between decision making and motor neural circuits becomes impaired and impedes rapid responses for those with mild cognitive impairment. Here the investiga…
Eligibility
- Age range
- 45–90 years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: 1. age 45 - 90 years 2. Perfect or corrected vision 3. Ability to reach 4. Neurotypical Age-Matched control participants - No history of neurological disorders or injury. 5. Mild Cognitive Impairment participants - clinical diagnosis of amnestic mild cognitive impairment. Exclusion Criteria: 1. Any injury or condition that impacts reaching 2. Traumatic brain injury, such as concussion, in the last 6 months. 3. Neurotypical Age-Matched control participants: Modified Telephone Interview for Cognitive Status (TICS-m) score \< 34 4. Mild Cognitive Impairment participants: Mo…
Interventions
- BehavioralReaching Movements
participants will perform a perceptual decision making task while moving their hand.
Location
- University of DelawareNewark, Delaware