Differential Thrombogenesis Effects of Eicosapentaenoic Acid (EPA) and Docosahexaenoic Acid (DHA) Mediated by High-Density Lipoprotein (HDL)
The Miriam Hospital
Summary
The goal of this study is to learn more about omega-3 polyunsaturated fatty acids supplementation on blood lipid profile and platelets in patients with high cholesterol levels. The purpose of this research is to gather information on the safety and effect of two different fish oils, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Participants will: Visit the clinic 3 times during study checkups, tests and blood collection. Randomized to either the EPA or the DHA supplementation group. Be given a 28-day food and activity log.
Description
Epidemiological studies suggest that consumption of omega-3 polyunsaturated fatty acids (n-3 PUFAs) derived from fish oil, mainly consisting of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), is associated with lower cardiovascular risk. However, interventional clinical trials aimed at reducing cardiovascular incidents by n-3 PUFAs supplementations have yielded inconsistent results. An intriguing fact is that only the outcome trials using EPA, but not those testing EPA/DHA mixed regimens, showed beneficial results. This discrepancy begs the question of whether EPA and DHA have diff…
Eligibility
- Age range
- 18–69 years
- Sex
- All
- Healthy volunteers
- No
Inclusion Criteria: * Fasting TG levels ≥ 150 mg/dL and \< 500 mg/dL and HDL-C ≤ 40 (men) or ≤ 50 (women) * LDL-C \> 40 mg/dL and ≤ 130 mg/dL * Able to provide informed consent and adhere to study schedules * Agree to follow and maintain a relatively stable and low fatty fish intake diet (\<3 servings per week) Exclusion Criteria: * Female with pregnancy, planned pregnancy (within the study period), or currently breastfeeding. * Subjects with weight changes greater than 20% over the past 3 months * Subjects planning a significant change in diet or exercise levels * Malabsorption syndrome an…
Interventions
- DrugEPA
Fish oil
- DrugDHA
Fish oil
Location
- Brown University Health - Lipid ClinicProvidence, Rhode Island