Myocardial Mechanisms in Heart Failure With Preserved Ejection Fraction (MM-HFpEF) A HeartShare Clinical Study
Northwestern University
Summary
The purpose of this study is to identify changes in heart tissue structure and biological function in patients with heart failure by performing an endomyocardial biopsy (EMB or heart biopsy) during a right heart catheterization (RHC). The ultimate goal is to use this information to develop new treatments for heart failure.
Eligibility
- Age range
- 30+ years
- Sex
- All
- Healthy volunteers
- Yes
Inclusion Criteria: * HFpEF criteria 1. Age ≥30 years. 2. Left ventricular ejection fraction ≥50% measured by echocardiography, CMR or MUGA (measured within one year + clinical stability) 3. Definition of HFpEF: signs and/or symptoms of HF, NYHA functional class II-IV, and at least one of the following: 1. Elevated BNP (≥75 pg/ml in sinus rhythm or ≥225 pg/ml in atrial fibrillation/flutter) or NTproBNP (≥225 pg/ml in sinus rhythm or ≥675 in atrial fibrillation/flutter) at baseline. Choice of BNP or NTproBNP is based on availability at each clinical center. 2. Prior HF hospit…
Locations (6)
- Northwestern UniversityChicago, Illinois
- Johns Hopkins UniversityBaltimore, Maryland
- Mass General BrighamBoston, Massachusetts
- Mayo ClinicRochester, Minnesota
- Wake Forest UniversityWinston-Salem, North Carolina
- University of PennsylvaniaPhiladelphia, Pennsylvania